Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patient

Fernanda Cristina A. Maranhão, Douglas L. H. Fonseca, Graciella S. A. Santos, Luisa Andrea V. Fonseca, Eduardo José L. Santos, Denise Maria W. Silva
2020 Jornal Brasileiro de Patologia e Medicina Laboratorial  
Cryptococcosis is caused by yeasts of the Cryptococcus neoformans/C. gattii complex, presenting cutaneous, respiratory and disseminated forms. A 44-year-old immunocompetent male with facial lesion and latent pneumonia was hospitalized and misdiagnosed with paracoccidioidomycosis. Computerized tomography scans showed pulmonary and neurological involvement, and cultures/China ink, cryptococcal antigen test and restriction fragment length polymorphism of urease gene (URA5-RFLP) confirmed C.
more » ... ans genotype VNI. Hemoculture indicated ampicillin-resistant Klebsiella pneumoniae (healthcare-associated infection). Fluconazole was administered, but after resistance detection, amphotericin B was chosen (cumulative dose/1500 mg). The patient was discharged with clinical remission (75 days) and amphotericin for one year (maintenance phase).
doi:10.5935/1676-2444.20200017 fatcat:chpnis7zbvdrxcz5qml6rbnt24