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Palytoxin disrupts cardiac excitation-contraction coupling through interactions with P-type ion pumps
American Journal of Physiology - Cell Physiology
Palytoxin is a coral toxin that seriously impairs heart function, but its effects on excitation-contraction (E-C) coupling have remained elusive. Therefore, we studied the effects of palytoxin on mechanisms involved in atrial E-C coupling. In field-stimulated cat atrial myocytes, palytoxin caused elevation of diastolic intracellular Ca 2ϩ concentration ([Ca 2ϩ ]i), a decrease in [Ca 2ϩ ]i transient amplitude, Ca 2ϩ alternans followed by [Ca 2ϩ ]i waves, and failures of Ca 2ϩ release. Thedoi:10.1152/ajpcell.00541.2003 pmid:15084477 fatcat:jpd64ilfqzfk3mpzipwzucknby