First observation of Hb Tunis [beta124(H2)Pro>Ser] in Turkey

Aylin Koseler, Hasan Koyuncu, Onur Ozturk, Anzel Bahadir, Sanem Demirtepe, Ayfer Atalay, Erol Omer Atalay
2010 Turkish Journal of Hematology  
Hb Tunis [beta124(H2)Pro>Ser] was reported from Tunisia in 1988. This hemoglobin variant was detected by isoelectric focusing moving just ahead of Hb A. It cannot be identified by standard hemoglobin electrophoresis due to its similar mobility to Hb A. It has normal stability and oxygen affinity and does not produce any clinical symptoms. Here, we report a heterozygous Hb Tunis [beta124(H2)Pro>Ser] case discovered for the first time in Turkey in a premarital screening program. This hemoglobin
more » ... riant can be identified with high performance liquid chromatography analysis confirmed with DNA sequencing. We emphasize in our study the importance of an interdisciplinary collaborative study at the provincial basis for the success of the hemoglobinopathy control program. (Turk J Hematol 2010; 27: 120-2)
doi:10.5152/tjh.2010.11 pmid:27263455 fatcat:apthyrzffvat7bjd4wwsgrfxgi