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REPARATION: ribosome profiling assisted (re-)annotation of bacterial genomes
2017
Nucleic Acids Research
Prokaryotic genome annotation is highly dependent on automated methods, as manual curation cannot keep up with the exponential growth of sequenced genomes. Current automated methods depend heavily on sequence composition and often underestimate the complexity of the proteome. We developed RibosomeE Profiling Assisted (re-)AnnotaTION (REPARATION), a de novo machine learning algorithm that takes advantage of experimental protein synthesis evidence from ribosome profiling (Ribo-seq) to delineate
doi:10.1093/nar/gkx758
pmid:28977509
pmcid:PMC5714196
fatcat:pdbsojhhqnho7nwt6ujcf7o2iq