Formulation and Characterization Transdermal Patches for Enhancing the Bio-Availability of Lisinopril Dihydrate

Rajendra Messa, Srinivas Ampati
2015 International Journal of Medicine and Nanotechnology   unpublished
___________________________________________________________________________________________ The present study was carried out to prepare Lisinopril Transdermal films for treating Hypertension. UV-Spectrophotometric analysis were performed for determination of Lisinopril in phosphate buffer pH 7.4 at 207 nm. FTIR Spectrum of pure drug and drug-polymer mixture revealed that there was no interaction. Eight formulations of Transdermal films were prepared by solvent casting technique using propylene
more » ... que using propylene glycol as plasticizer and SPAN20 as permeation enhancer and different polymers like HPMC K4M, HPMC K15M, Eudragit RS100 and Eudragit RL100. Various physicochemical parameters like film thickness, weight variation, drug content, folding endurance, moisture content and in vitro diffusion study were evaluated. The in vitro diffusion kinetics of the Transdermal films were calculated.The maximum drug diffusion was attained at 12 h by formulation F3. In zero order kinetics the regression value of formulation F3 was found to be 0.992. Stability study of F3 formulation was performed and that showed no significant change in physicochemical parameters and drug diffusion.