Suppressive effects of breast milk on oxidative DNA damage in very low birthweight infants

H Shoji
2004 Archives of Disease in Childhood: Fetal and Neonatal Edition  
Human milk contains many kinds of antioxidant and is considered to prevent diseases mediated by oxygen free radicals in very low birthweight (VLBW) infants. Aims: To examine the antioxidant effects of breast milk in VLBW infants by determining urinary 8hydroxydeoxyguanosine (8-OHdG) excretion, which is known to be a non-invasive marker for in vivo oxidative DNA damage. Methods: Urinary 8-OHdG concentrations were measured in 15 breast fed and 14 formula fed VLBW infants at 2, 7, 14, and 28 days
more » ... 7, 14, and 28 days of age. Results: Urinary 8-OHdG excretion at 14 and 28 days of age was significantly lower than at 2 and 7 days of age in the breast fed group, and significantly lower than in the formula fed group. Conclusion: This is the first direct evidence of the antioxidant action of human milk in VLBW infants.
doi:10.1136/fn.89.2.f136 fatcat:y6g234uwyzapfeaxystcz6a224