Chemically Modified Natural Substances Screening for Biofilms Inhibition and Biofouling Control

M.D.G. Silva, D. Almeida, R.D.C. Soares Da Silva, H. Meira, F. Almeida, M. Fernandes, A.K.P. Silva, A. Dos Santos V, L. Sarubbo
2018 Chemical Engineering Transactions  
Biofilms can be characterized as a microorganisms community attached to a surface and enveloped by an extra polymeric substances complex array in a moist environment. It is known that the growth and formation way of the biofilm structure induces resistance to several microbial agents, making it impossible to disintegrate and eliminate these structures. These biofilms can settle in the vessels surface, pipes, thermoelectric cooling systems and so forth causing serious economic problems in the
more » ... problems in the most diverse strategic sectors of a country such as nautical, industrial, energy. Search for substances capable of disturbing this formation is desired, since the formation of the biofilm is the crucial stage for the emergence of new organisms that will develop until the climax of the ecological succession with the arrival of macrofouling. These substances when isolated can be ideal inputs for the development of antifouling products and be incorporated into paints and coatings. Thus, the present study aim was synthesize antibacterial substances through chemical modification of natural substances, obtained from vegetable oils, specifically soybean oil (Glycine max (L.)). Selected substances and their variants for the synthesis were chosen based on/supported by studies that demonstrated the antifouling potential of some types of fatty acids and the efficacy of monoglycerides in combating the formation of biofilms. The following substances were synthesized: 9,10-dihydroxy octadecanoic acid; 9,10-dihydroxy octadecanoate; 9- octadecenoate 2,3-dihydroxypropanoyl; 2,3-dihydroxypropanoyl dodecanoate and 9,10-dihydroxy octadecanoate 2,3-dihydroxypropanoyl. For the synthesis of the substances, neutralization reactions using a catalyst base as well as esterification reactions with a polyalcohol (glycerol) and/or hydroxylation reactions by epoxidation were performed. To assess the antimicrobial activity, a rapid antibiogram assay was developed to observe the bacterium Pseudomonas aeruginosa UCP0992 growth obtained from the Cultures Colle [...]
doi:10.3303/CET1864110 doaj:b5c687911c04499397a32a739bb6126d fatcat:2yr4d7rygbcldphdmjco5b3igq