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Cannabinoids produce anti-nociceptive and anti-hyperalgesic effects in acute, inflammatory and neuropathic pain models. The current study investigated the role of cannabinoid (CB1 and CB2) receptors in modulating formalin-induced nociceptive behavior and mechanical allodynia in the rat. Rats received subcutaneous plantar injections of 5% formalin in the hind paws. Licking, biting and paw flinching nociceptive behaviors were measured 0-60 min after formalin injection. Allodynia was measured at 3doi:10.4077/cjp.2015.bad307 pmid:25687494 fatcat:t5vma53sz5duxlmhgpsbnxeok4