Terpenes as Potential Antimalarial Drugs [chapter]

Heloisa Berti Gabriel, Rodrigo AC Sussmann, Emila A Kimura, Adriana Alejandra Marin Rodriguez, Ignasi Bofill Verdaguer, Gabriela Carolina Fernandes Leite, Alejandro Miguel Katzin
2018 Terpenes and Terpenoids  
A fact which favors the increase in morbidity and mortality of malaria cases in the world is the resistance to chemotherapeutic agents that the parasite presents. Therefore, it is necessary to identify new potential targets specific to the parasite in order to be able to perform a rational planning. One target for the evaluation of potential antimalarial compounds is isoprenoid synthesis, which occurs via the 2-C-methyl-d-erythritol-4-phosphate pathway in Plasmodium falciparum. Several
more » ... aries and final products of this pathway were identified in the parasite and lead us to the conclusion that it is different from the vertebrate host. In this chapter, we describe the effect of some monoterpenes and sesquiterpenes on Plasmodium falciparum and Plasmodium berghei as potential antimalarial drugs.
doi:10.5772/intechopen.75108 fatcat:xtc4izkbk5frbe5hcczqjbhz3m