Recognition of rabies and rabies-related viruses by T cells derived from human vaccine recipients

E Celis, D Ou, B Dietzschold, H Koprowski
1988 Journal of Virology  
Human peripheral blood mononuclear cells and T-cell lines and clones from individuals immunized with rabies PM vaccine were tested for the ability to recognize antigenic determinants in rabies and rabies-related viruses in an antigen-induced proliferation assay. Some, but not all, of the T cells from these individuals cross-reacted with various laboratory strains of rabies virus and with rabies-related viruses such as Duvenhage and Mokola. In addition, these T cells were shown to react with
more » ... opes of either the ribonucleoprotein or the viral glycoprotein. Rabies-specific cytotoxic T-cell responses by a CD4+ T-cell line were evident against antigenic determinants of the ribonucleoprotein and glycoprotein.
doi:10.1128/jvi.62.9.3128-3134.1988 fatcat:h3ndsut6qjdwplixalo33apsza