Subependymal Giant Cell Astrocytoma Associated with Tuberous Sclerosis: With Special Reference to Cell Kinetic Studies

Takafumi NISHIZAKI, Tetsuji ORITA, Seisho ABIKO, Hideo AOKI, Haruhide ITO
1990 Neurologia medico-chirurgica  
The authors report a case of subependymal giant cell astrocytoma associated with tuberous sclerosis in a 15-year-old boy. Computed tomographic scans showed a large intraventricular mass with peritumoral calcification and a cyst in the left lateral ventricle. Left dominant unilateral hydrocephalus was also revealed. Magnetic resonance images clearly demonstrated the lesion. The tumor was subtotal ly removed and a ventriculoperitoneal shunt was performed because of the hydrocephalus. The pro
more » ... ation potential was assessed by measuring the bromodeoxyuridine (BUdR) labeling index employ ing the in vitro labeling method, and determining the deoxyribonucleic acid (DNA) content by flowcytometry. BUdR-positive cells were found to be rare, and the DNA histogram demonstrated no evidence of high proliferative activity or aneuploidy.
doi:10.2176/nmc.30.695 pmid:1708461 fatcat:sprj6cynzfbejf66x2majx64l4