QUINOLINAS: PROMISSORES SCAFFOLDS PARA FUTUROS AGENTES ANTIINFLAMATÓRIOS

S. E. B. SILVA, M. L. ALMEIDA, I. R. PITTA, M. G. R. PITTA
2017 Anais do 5º Encontro Brasileiro para Inovação Terapêutica   unpublished
Palavras-chave: anel quinolínico, ação anti-inflamatória, AINEs ABSTRACT -The quinoline ring is responsible for several pharmacological activity. Among them, it has anti-inflammatory action. NSAIDs are widely used in the fight against the inflammatory process that affects some diseases. There are several studies that evaluate quinoline derivatives with the most varied organic functions linked to the ring, as well as amine groups and electronegative atoms that make these molecules interesting
more » ... ules interesting drug candidates. The objective of this work is to gather the most recent articles and list the characteristics of the molecules observing their similarities, differences and parameters related to the Rule of the five of Lipinski. Among the 26 papers presented, many compounds fall under the rule and the similarities between them stand out. In this review we can find the most active molecules of scientific articles in a period of 10 years (2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017), and can serve as a basis for the planning of potent, safe and effective compounds, and less likely to be eliminated in the different phases of the chain production of drugs.
doi:10.17648/ebit-2017-85741 fatcat:4zrr7lmlircyppyk5cyufxvjhi