The Influence of Weight Loss on Arterial Stiffness in Obese and Overweight Subjects

Viviana Elian, Cristian Panaite, Dan Cheta, Cristian Serafinceanu
2012 Romanian Journal of Diabetes Nutrition and Metabolic Diseases  
Objectives: The Metabolic Syndrome (MetS) and obesity are among the proven causes of vascular dysfunction. The cardio-ankle vascular index (CAVI) was developed as a method to assess arterial stiffness. The aim of the study was to establish the influence of weight loss on arterial stiffness parameters. Material and Methods: 135 subjects completed a 6 months standardized life style intervention study. Average initial weight was 96.63kg with a BMI of 34.34kg/m2. CAVI and the ankle-brachial index
more » ... BI) were measured and body composition was assessed. Some biochemical markers were also determined. Results: The average weight decreased to 84.61kg, with fat mass loss of 9.6 kg. Mean CAVI decreased from 7.92±1.28 to 7.21±1.08. The decrease in CAVI correlates with the total weight and fat loss rather than the speed of weight loss. Conclusions: Our results show that weight loss can influence arterial stiffness, mainly by decreasing fat tissue mass. key words: obesity, arterial stiffness, weight loss, lifestyle intervention.
doi:10.2478/v10255-012-0041-1 fatcat:6ab4cbb45zexrc42tkgng6cc6q