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Ectopic expression of MHC II molecules on glandular cells is a feature of primary Sjögren's syndrome (pSS). However, the cause of this ectopic expression and its potential role in the pathogenesis of the disease remains elusive. Here, we report that ectopic expression of MHC II molecules on glandular cells represents an early presymptomatic event in a mouse model of pSS induced by immunization of Ro60_316-335 peptide emulsified in TiterMax ® as an adjuvant. Ectopic expression of MHC II wasdoi:10.3389/fimmu.2018.02362 fatcat:gsdycqrrojfpvjhntut4aqo36q