Low-dose warfarin in high-risk pregnant patients with mechanical valves: A randomized clinical trial

Ahmed Hassouna, Ayman Ammar, Yasser Elnahas, Ahmed Toema, Hemat Allam
2014 Egyptian Heart Journal  
hyperintensities were scored according to the modified Scheltens score. Significance level for the used tests is p = 0.05. Results: The mean age was 68.8 AE 3.4 years old. The distribution of gender, smoking and dyslipidemia among the 4 groups was not significant. The hypertension duration, office and 24-h ABPM BP measurements and MRI score varied significantly between the 4 groups (p < 0.0005). The hypertension duration and the average awake systolic blood pressure had the stronger impact on
more » ... e MMSE class of the patient (R 2 = 0.87, p < 0.0005). Classifying the patients into controlled and uncontrolled hypertensives, we had a higher percentage of uncontrolled BP in every cognitive impairment class. Only 1 patient with normal cognitive function had an uncontrolled hypertension. MMSE score has a sensitivity and specificity of 94% and 83% respectively in the prediction of uncontrolled hypertension. Conclusion: We conclude that MMSE is a simple test to run in clinic and can give an idea about the degree of structural damage caused to the brain; and hence predict whether or not the patient's BP is well controlled. This would not replace the 24-hour ABPM but may help guide the clinicians to request this 24-hour monitoring. http://dx.
doi:10.1016/j.ehj.2013.12.039 fatcat:lpfo5lm5vzdxvp2lirq7redwbm