Synthesis, Antibacterial and Antioxidant Properties of Newer 1,2-benzoxaphosphol-2-ones

A Bala Krishna, K Suresh Kumar, K Ramesh, C Suresh Reddy, S Nayak
2009 Der Pharma Chemica   unpublished
A new series of 5-chloro-3-(4-substituted anilino)-2-phenyl-2,3-dihydro-1,2λ 5-benzoxaphosphol-2-ones 4a-j have been prepared via Mannich type reaction by reacting 5-chlorosalicyaldehyde 1 with phenyl dichlorphosphine 2 and aromatic amines 3a-j in anhydrous benzene under reflux condition. Their chemical structures were characterized by using 1 H, 13 C, 31 P and mass spectral studies. All the title compounds were screened for antioxidant properties by radical scavenging methods such as
more » ... s such as 1,1-dipheyl-2-picryl hydrazyl (DPPH), Reducing power and H 2 O 2 scavenging methods. They exhibited potent in vitro antioxidant activity dose dependently. Their bioassay showed that they possess significant antibacterial activity.