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Heart failure is an increasingly common diagnosis, with a dismal prognosis that is worse even than many types of cancer (Ho et al., 1993) . There are few therapeutic options. The estimated cost of heart failure is currently between 1-2% of the total healthcare spend in developed economies and is expected to rise (McMurray and Stewart, 2000) . Clinical presentation may be insidious or acute, with decreased exercise tolerance and shortness of breath. Cardiac arrhythmias may accompany heartdoi:10.1242/dmm.005017 pmid:20212081 fatcat:lfkybyqmjzbnxhptijmnjkc4ey