The main aim of the present research work is to isolate the carotenoid lycopene from the ethanolic extract of Water melon (EEWM) and evaluate the cytotoxic activity against HT-29 cell line. The isolation of lycopene from EEWM was carried out by UV, IR, 1 H-NMR, 13 C-NMR, Mass spectra, and HPLC. The cytotoxic potentiality of EEWM was performedby SRB assay against human colorectal adenocarcinoma HT29 cell line.The results obtained from the in-vitro studies displayed that the ethanolic extracts

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... hefruit of Citrullus vulgaris L. (EEWM) possessed a very good cytotoxic activity againsthuman colorectal adenocarcinomaHT-29cell line.From the present experimental data it had been concluded that EEWM was exhibiting the potential capability to inhibit the growth of cancer cell when compared with standard drug 5-FU and the cell growth inhibition of EEWM was found to be the highest92.95% at 10 µg (IC 50 = 2.7 µg/ml).The IC 50 value of standard drug 5-FU was found to be 1.399 µg/ml with 95.97 %growth inhibition at concentration 75 µg/ml.