Detection of 11q23 (MLL) rearrangements in infant acute lymphoblastic leukemia

G. A. Tsaur, A. M. Popov, O. V. Aleynikova, E. G. Boychenko, T. Yu. Verzhbitskaya, E. V. Volochnik, A. S. Ivanova, O. V. Kalennik, S. Yu. Kovalev, K. L. Kondtratchik, A. M. Kustanovich, E. S. Lapotentova (+15 others)
2014 Onkogematologiâ  
117 cases of infant acute lymphoblastic leukemia without Down syndrome (aged from 1 to 365 days) were included in the current study.Rearrangements of 11q23 (MLL) were revealed in 74 (63.2 %) patients. Among this group the most common rearrangement was t(4;11) q21;q23)/MLL-AF4 detected in 63.5 % cases, less frequently was found t(11;19)(q23;p13)/MLL-MLLT1 (in 18.9 % cases), t(10;11) p12;q23)/MLL-MLLT10 and t(1;11)(p32;q23)/ML L-EPS15 (each one in 6.8 %), t(9;11)(p22;q23)/MLL-MLLT3 in 2.7 %.
more » ... LLT3 in 2.7 %. Children under 6 months of age had significantly higher incidence of 11q23 (ML L) rearrangements in comparison with infants olde r than 6 months (84.0 % vs. 47.8 %, p < 0.001). P atients with translocations 11q23 (ML L) more frequently had BI-A LL and less frequently BII-ALL than children without these rearrangements (p < 0.001 f or both). Fusion gene transcript w as sequenced in 26 ML Lrearranged cases. Depending on breakpoint position within ML L and partner genes we detected 7 differ ent types of ML L-AF4 fusion gene transcript, 3 types of MLL-MLLT1, 2 types of MLL-EPS15. The most common fusion site within MLL gene was exon 11, detected in 14 (53.8 %) patients.
doi:10.17650/1818-8346-2011-6-3-57-64 doaj:4bfa81f4024c4578befd7cdbdb10d236 fatcat:t5zoeg3ymbf63nqqxfn5vpclgi