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Elucidating synergistic dependencies in lung adenocarcinoma by proteome-wide signaling-network analysis
2019
PLoS ONE
To understand drug combination effect, it is necessary to decipher the interactions between drug targets-many of which are signaling molecules. Previously, such signaling pathway models are largely based on the compilation of literature data from heterogeneous cellular contexts. Indeed, de novo reconstruction of signaling interactions from large-scale molecular profiling is still lagging, compared to similar efforts in transcriptional and protein-protein interaction networks. To address this
doi:10.1371/journal.pone.0208646
pmid:30615629
pmcid:PMC6322741
fatcat:73xsxhy35zhq7f2lkxakzibbly