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Key Words phosphatidylinositol 4,5-bisphosphate, phosphoinositides, signal transduction, second messengers s Abstract We review the physical properties of phosphatidylinositol 4,5-bisphosphate (PIP 2 ) that determine both its specific interactions with protein domains of known structure and its nonspecific electrostatic sequestration by unstructured domains. Several investigators have postulated the existence of distinct pools of PIP 2 within the cell to account for the myriad functions of thisdoi:10.1146/annurev.biophys.31.082901.134259 pmid:11988466 fatcat:sqg5xcgiajhuhii6yy5h7e76qq