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In economic evaluation, different parametric or non-parametric methods can be used to assess the survival benefit from individual patient data. A challenge, when using individual patient data from a meta-analysis to estimate the survival benefit, is to take into account stratification on clinical trials. Our objective was to compare five different methods to estimate survival benefit and to investigate the impact on the health economic outcome. We chose to compare four non parametric methodsfatcat:h327nx54crfdrhryhmx4ssfz2u