The progesterone receptor is differentially expressed in brain metastatic breast cancer [post]

Shahan Mamoor
2020 unpublished
Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the progesterone receptor, encoded by PGR, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast.
more » ... e observed a significant correlation between PGR expression in primary tumors of the breast and distant metastasis-free survival, as well as overall survival. Down-regulation of PGR may be an important event for metastasis of primary tumor-derived cancer cells to the brain in humans with metastatic breast cancer, and irrespective of its importance, appears to be a transcriptional event generally associated with metastasis to the brain.
doi:10.31219/osf.io/4w9tu fatcat:juufcd6o2zazzkwu6ncxc6nj2y