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The paper analyzes the scientific data included the author's own results about the opportunities to increase the reproductive potential of female animals by application of the natural no hormonal substances and the supposed mechanisms of their action on the reproductive system. Also the new scientific data related to the discovering of the "metabolic" hormones (leptin, ghrelin) and kisspeptin/GPR54 system as well as their relationship with metabolism and reproductive function in animals is discussed.doi:10.2298/bah1103365a fatcat:njptb7vuabdfpkktdkou7vtaui