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In diagnosing coronary artery disease, measurement of the cross-sectional area of the lumen, maximum and minimum diameter is very important. Mainly, it will be used to confirm the diagnosing, to predict the stenosis if any and to ensure the size of the stent to be used. However, the measurement only offers by the existing software and some of the software needs human interaction to complete the process. The purpose of this paper is to present the algorithm to measure the region of interestdoi:10.11591/eei.v10i1.2694 fatcat:sgipmgg63vhn5p6lmqzyxztkn4