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Genes & Development
The RNA polymerase II general transcription factor TFIID is a multisubunit complex comprising TATA-box binding protein and associated factors (TAFIIS). In vitro experiments have suggested that TAFIIS are essential coactivators required for RNA polymerase II-directed transcription activation. Here, for the first time, we analyze systematically the in vivo function of a specific TAFt, yeast TAFn90 (yTAFu90). We show that functional inactivation of yTAFH90 by temperature-sensitive mutations ordoi:10.1101/gad.10.18.2368 pmid:8824595 fatcat:nxhe46qgbvckvdke46gup4mjm4