FRI0392 Opportunistic infections in patients with myositis. a retrospective cohort study

A Redondo-Benito, A Curran-Fàbregas, A Villar-Gomez, E Trallero-Araguás, A Fernandez-Codina, I Pinal-Fernandez, A Selva-O'Callaghan
2017 Poster Presentations   unpublished
Objectives: To evaluate clinical utility of perfusion and myocardial fatty acid metabolism mismatch in SSc patients without cardiac failure. Methods: All patients who visited St. Marianna University Hospital from 2009 to 2015 and performed cardiac scintigraphy using 99m Tl and 123 I-BMIPP were retrospectively evaluated. Patients who fulfilled American Collage of Rheumatology classification criteria of SSc and systemic lupus erythematosus (SLE) were selected. We subtracted %uptake of metabolism
more » ... 123 I-BMIPP) from that of perfusion ( 99m Tl) on each 17 myocardial segments standardized by American Heart Association. We compared sum of all the scores and each score in 3 coronary artery regions between patients with SSc and SLE. Furthermore, we evaluated incidence of cardiac death or cardiac failure depending on the scores of each coronary artery regions. Results: Among 177 patients, we analyzed the data in 22 cases with SSc and 23 with SLE. The sum of all mismatch scores was not significantly different between the 2 groups (p=0.37). The mismatch score of left anterior descending coronary artery (LAD) region was significantly higher in SSc than SLE (p=0.05) ( Figure 1A ). We next divided SSc patients into 2 groups depending on degree of the LAD mismatch score and found the group with low score had higher incidence of cardiac death or cardiac failure (p=0.04) than that with high score ( Figure 1B) .
doi:10.1136/annrheumdis-2017-eular.4829 fatcat:op3zklptezevrnfkcvzb6n3e2q