Lower respiratory tract infection is a common condition associated with considerable morbidity and mortality. The management of lower respiratory tract infection is complicated by the increasingly recognized spectrum of pathogens associated with this disease and their antibiotic susceptibility patterns. Fluoroquinolone antibiotics have a wide spectrum of activity that covers the common respiratory pathogens. However, the perceived limitations of older fluoroquinolones against S. pneumoniae have

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... led to a reluctance to use these agents in respiratory tract infection. The newer fluoroquinolones retain the good activity against Gram-negative organisms and "atypical" respiratory pathogens of older agents, while providing extended Gram-positive activity. Keywords-SAR of fluoroquinolones