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Macrolide resistance was found in 39.5% of 3626 nonduplicate Streptococcus pneumoniae isolates from adult ambulatory and inpatient settings at 329 US hospitals (2018-2019). Macrolide resistance was significantly higher for respiratory vs blood isolates and ambulatory vs inpatient admissions. Despite geographic variation, S. pneumoniae-macrolide resistance was >25% in most regions.doi:10.1093/ofid/ofab063 pmid:34250183 pmcid:PMC8266646 fatcat:nvwequescjgdfhl27gtogj6rli