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miRNA-1290 Promotes Aggressiveness in Pancreatic Ductal Adenocarcinoma by Targeting IKK1
2018
Cellular Physiology and Biochemistry
Background/Aims: MicroRNAs (miRNAs) are a group of non-coding RNAs that play diverse roles in pancreatic carcinogenesis. In pancreatic ductal adenocarcinoma (PDAC), NF-kB is constitutively activated in most patients and is linked to a mutation in KRAS via IkB kinase complex 1 (IKK1, also known as IKKa). We investigated the link between PDAC aggressiveness and miR-1290. Methods: We used miRCURY™ LNA Array and in situ hybridization to investigate candidate miRNAs and validated the findings with
doi:10.1159/000495328
pmid:30463064
fatcat:ziabynpoyvakne3ab5kca2u7ie