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Cell therapy in Huntington's disease
2004
Neurotherapeutics
Huntington's disease is an autosomal dominant genetic disease, which results in progressive neuronal degeneration in the neostriatum and neocortex, and associated functional impairments in motor, cognitive, and psychiatric domains. Although the genetic mutation is identified, involving an abnormal CAG expansion within the htt gene on chromosome 4, the mechanism by which this leads to neuronal cell death and the question of why striatal neurones are targeted both remain unknown. Thus, in
doi:10.1007/bf03206626
fatcat:soqx3kh4hnhhbpglhfwjo3dpom