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The age of onset was 6-17 years (mean 11 yrs; 8 boys, 8 girls). Presenting symptoms and signs in order of frequency were cerebellar, pyramidal, optic neuritis, cranial nerve/brain stem signs, myelopathy, sensory, and increased intracranial pressure. CSF protein was normal in 11/12 patients tested, IgG index or oligoclonal bands were informative in 75%, evoked potentials abnormal in 70%, EEG abnormalities in 83%, MRI showed multiple plaques with increased density in T2-weighted images in 80%,doi:10.15844/pedneurbriefs-10-4-9 fatcat:rf7dnb2m6bfalamv6wqkcr6fdy