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SALMANTICOR study. Rationale and design of a population-based study to identify structural heart disease abnormalities: a spatial and machine learning analysis

Jose Ignacio Melero-Alegria, Manuel Cascon, Alfonso Romero, Pedro Pablo Vara, Manuel Barreiro-Perez, Victor Vicente-Palacios, Fernando Perez-Escanilla, Jesus Hernandez-Hernandez, Beatriz Garde, Sara Cascon, Ana Martin-Garcia, Elena Diaz-Pelaez (+12 others)
2019 BMJ Open  

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IntroductionThis study aims to obtain data on the prevalence and incidence of structural heart disease in a population setting and, to analyse and present those data on the application of spatial and machine learning methods that, although known to geography and statistics, need to become used for healthcare research and for political commitment to obtain resources and support effective public health programme implementation.Methods and analysisWe will perform a cross-sectional survey of
more » ... y selected residents of Salamanca (Spain). 2400 individuals stratified by age and sex and by place of residence (rural and urban) will be studied. The variables to analyse will be obtained from the clinical history, different surveys including social status, Mediterranean diet, functional capacity, ECG, echocardiogram, VASERA and biochemical as well as genetic analysis.Ethics and disseminationThe study has been approved by the ethical committee of the healthcare community. All study participants will sign an informed consent for participation in the study. The results of this study will allow the understanding of the relationship between the different influencing factors and their relative importance weights in the development of structural heart disease. For the first time, a detailed cardiovascular map showing the spatial distribution and a predictive machine learning system of different structural heart diseases and associated risk factors will be created and will be used as a regional policy to establish effective public health programmes to fight heart disease. At least 10 publications in the first-quartile scientific journals are planned.Trial registration numberNCT03429452.
doi:10.1136/bmjopen-2018-024605 pmid:30765403 pmcid:PMC6398793 fatcat:efps2df5sbhppeplkgmowafqci
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Jose Ignacio Melero-Alegria, Manuel Cascon, Alfonso Romero, Pedro Pablo Vara, Manuel Barreiro-Perez, Victor Vicente-Palacios, Fernando Perez-Escanilla, Jesus Hernandez-Hernandez, Beatriz Garde, Sara Cascon, Ana Martin-Garcia, Elena Diaz-Pelaez, Jose Maria de Dios, Aitor Uribarri, Javier Jimenez-Candil, Ignacio Cruz-Gonzalez, Baltasara Blazquez, Jose Manuel Hernandez, Clara Sanchez-Pablo, Inmaculada Santolino, Maria Concepcion Ledesma, Paz Muriel, P Ignacio Dorado-Diaz, Pedro L Sanchez. "SALMANTICOR study. Rationale and design of a population-based study to identify structural heart disease abnormalities: a spatial and machine learning analysis." BMJ Open 9.2 (2019) e024605