International Journal of Research in Pharmacy and Science A Pharmacodynamic Pilot Study to Evaluate the Effect of Gatifloxacin and Glyburide Alone and in Combination on Plasma Glucose and Serum Insulin Levels in Healthy Human Subjects

Arora Tarun, Anand Gaurav, Sharma Sumeet, Gupta Nakul, Tandon Monika, Tarun Arora, Arora Tarun
2011 IJRPS   unpublished
Although some drug related problems develop unexpectedly and cannot be predicted, many are related to known pharmacological actions of drugs and reasonably can be anticipated. However, as the drug therapy become more complex and because many patients are being treated with two or more drugs, the ability to predict the magnitude of a specific action of any given drug diminishes. These circumstances require not only maintenance of complete and current medications records for patients, but also
more » ... tients, but also for closer monitoring and supervision of the drug therapy so that problems could be prevented or detected at an early stage in the treatment. The dearth of reports on glyburide-gatifloxacin interaction leading to hypoglycemia is surprising, given rather broad use of both these drugs. There have been rare postmarketting reports of hypoglycemia in patient's concurrently taking glyburide and gatifloxacin. Possibly, hypoglycemia may be inadvertently attributed solely to glyburide, either because concomitant use of both the medicines is not well documented, or because of lack of appreciation of possibility of such a reaction by medical professionals. In the present study, accordingly, case reports served as a stimulus to evaluate the effects of gatifloxacin and glyburide alone and in combination on plasma glucose and serum insulin levels in healthy, adult, male, human volunteers and to assess the safety and tolerability of concomitant administration. The results of the study indicated that gatifloxacin when given alone or in combination with glyburide had influence on plasma glucose and serum insulin levels in time specific manner. The effect did result in significant oscillations in plasma glucose and serum insulin levels.