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Endothelial Shear Stress: A Critical Determinant of Arterial Remodeling and Arterial Stiffness in Humans--A Carotid 3.0-T MRI Study
2010
Circulation Cardiovascular Imaging
Background-Low endothelial shear stress (ESS) elicits endothelial dysfunction. However, the relationship between ESS and arterial remodeling and arterial stiffness is unknown in humans. We developed a 3.0-T MRI protocol to evaluate the contribution of ESS to arterial remodeling and stiffness. Methods and Results-Fifteen young (aged 26Ϯ3 years) and 15 older (aged 57Ϯ3 years) healthy volunteers as well as 15 patients with cardiovascular disease (aged 63Ϯ10 years) were enrolled. Phase-contrast MRI
doi:10.1161/circimaging.109.916304
pmid:20576811
fatcat:dc7l543xobd7xnyo6owbi6f3i4