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Protein structure, amino acid composition and sequence determine proteome vulnerability to oxidation‐induced damage
2020
EMBO Journal
Oxidative stress alters cell viability, from microorganism irradiation sensitivity to human aging and neurodegeneration. Deleterious effects of protein carbonylation by reactive oxygen species (ROS) make understanding molecular properties determining ROS susceptibility essential. The radiation-resistant bacterium Deinococcus radiodurans accumulates less carbonylation than sensitive organisms, making it a key model for deciphering properties governing oxidative stress resistance. We integrated
doi:10.15252/embj.2020104523
pmid:33073387
fatcat:vwspyunzabgo5gbcukrlmpf4zu