Autoimmune Thyroid Disease Genes Identified in Non-Caucasians

Yoshihisa Ban, Yoshiyuki Ban, Yoshio Ban
2012 Open Journal of Endocrine and Metabolic Diseases  
Autoimmune thyroid diseases (AITDs), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), are among the commonest autoimmune disorders, affecting approximately 2% -5% of the population. Epidemiological data support strong genetic influences on the development of AITD. The identification of genes placing individuals at an increased risk for the development of AITD has been a slow process. However, over the last 20 years or so real progress has been made with the mapping of novel
more » ... pping of novel loci, via a number of different approaches. The first AITD gene discovered, Human Leucocyte Antigen (HLA)/Major Histocompatibility Complex (MHC), is associated with both GD and HT. Non-MHC genes that confer susceptibility to AITD can be classified into two groups: (1) immune-regulatory genes (e.g., CD40, CTLA-4, and PTPN22); (2) thyroid-specific genes-thyroglobulin and TSH receptor genes. These genes interact with environmental factors, such as infection, likely through epigenetic mechanisms to trigger disease. In this review, we will summarize the latest findings on AITD susceptibility genes in non-Caucasians. The thyroglobulin (Tg) protein is the major thyroidal protein antigen and is a precursor to thyroid hormones.
doi:10.4236/ojemd.2012.24017 fatcat:sssv5jpilnbavjrxjuqbktdg4i