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We assessed natural killer activity of lymphocytes present at the site of human tumors to determine the local effects of the tumor on immune function. Lymphocytes were extracted from human pulmonary tumors of varying histological types. In addition to tumor-infiltrating lymphocytes (TIL), peripheral blood lymphocytes from the same patients were prepared. Using a Michaelis-Menten kinetic model and titration of K562 targets in a 51Cr release assay, TIL exhibited a marked depression of maximalpmid:3855286 fatcat:aeknoqnhdbaijjse5ccsiwwcsi