This current review was aimed to evaluate the screening strategies and treatment approaches for migraine headache attacks, also to discuss the risk factors associated with this serious neurological disorder. Targeted detailed search was conducted through databases; PubMed/Midline, and Embase, for these articles disusing the migraine from different aspects and mostly diagnostic procedures and treatment options, with human subjects published up to end of 2016, We restricted this search to only

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... lish language published articles. To be able to approach the precise therapy choice a comprehensive medical diagnosis has to be executed among patients believed with migraine headache. This review stresses the functional therapy of migraine headache in addition to the development that has actually been made in specifying migraine pathophysiology as well as in developing new particular treatments. There is overlapping reaction to therapy: non-steroidals, triptans, dihydroergotamine, as well as the anti-emetic dopamine-antagonists may play a restorative role for every of these acute headaches.