Zeatin Supplement Improves Scopolamine-Induced Memory Impairment in Mice

Mi Jeong KIM, Soo Jung CHOI, Seung-Taik LIM, Hye Kyung KIM, Young Jun KIM, Ho-Geun YOON, Dong-Hoon SHIN
2008 Bioscience, biotechnology and biochemistry  
In this study, our aim was to clarify the ameliorative effects of zeatin, a development hormone in plants. Zeatin mitigated cognitive deficits and showed AChE inhibition in scopolamine (Scop)-induced mice following 21 d of zeatin treatment. After administration of Scop for 30 min, each mouse performed Y-maze and stepdown latency tasks as a check on immediate against cognitive function. The results showed that zeatin administration attenuated Scop-induced memory damage and decreased AChE
more » ... reased AChE activity in the mice. This suggests that zeatin might be useful for protecting cognitive dysfunction, as well as for reducing the activation of AChE in dementia.
doi:10.1271/bbb.70480 pmid:18256461 fatcat:osha2y2wijdlnnfmstsk3olbem