Goal-Directed Therapy for General ICU Patients Using Aggregated Multi-Objective Optimisation

A. Wang, G. Panoutsos, M. Mahfouf, G.H. Mills
<span title="">2008</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/p3wtlm3j2fedxitkuu4bs3scau" style="color: black;">IFAC Proceedings Volumes</a> </i> &nbsp;
SOPAVent (Simulation of Patients under Artificial Ventilation) is a blood gas model able to simulate patient ventilatory parameters subject to mechanical ventilation in the intensive care unit (ICU). In this paper, the SOPAVent model is further developed into a continuously updated model of patient ventilatory condition. The extended version of the model is used as the core component for a goal-directed optimisation strategy which aims to provide adaptive decision support for ventilatory
more &raquo; ... . Two objective functions are aggregated in an effort to interpret medical goals into an optimisation problem. The settings of the optimisation strategy are fine-tuned based on medical-goals and medical prioritization rather than mathematical optimality of solutions. The final decision support system is tested via a series of closed-loop simulations by assuming different clinical scenarios. Results show that the decision support system provides the correct advice for ventilator settings following adequate prioritization of competing medical goals.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3182/20080706-5-kr-1001.01530">doi:10.3182/20080706-5-kr-1001.01530</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ere2w3pcfvdk3fjy6orjuwd4d4">fatcat:ere2w3pcfvdk3fjy6orjuwd4d4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170812170556/http://folk.ntnu.no/skoge/prost/proceedings/ifac2008/data/papers/2537.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1e/11/1e11366aefa44bd652bad39defbad14cf754b870.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3182/20080706-5-kr-1001.01530"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>