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Goal-Directed Therapy for General ICU Patients Using Aggregated Multi-Objective Optimisation
<span title="">2008</span>
<i title="Elsevier BV">
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SOPAVent (Simulation of Patients under Artificial Ventilation) is a blood gas model able to simulate patient ventilatory parameters subject to mechanical ventilation in the intensive care unit (ICU). In this paper, the SOPAVent model is further developed into a continuously updated model of patient ventilatory condition. The extended version of the model is used as the core component for a goal-directed optimisation strategy which aims to provide adaptive decision support for ventilatory
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... . Two objective functions are aggregated in an effort to interpret medical goals into an optimisation problem. The settings of the optimisation strategy are fine-tuned based on medical-goals and medical prioritization rather than mathematical optimality of solutions. The final decision support system is tested via a series of closed-loop simulations by assuming different clinical scenarios. Results show that the decision support system provides the correct advice for ventilator settings following adequate prioritization of competing medical goals.
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