Dynamic Deconstructive Psychotherapy has used neuroscience findings to propose the specific neuroaffective deficits in processing of the emotion experiences as etiology of the borderline personality disorder. The purpose of this study was to evaluate the efficacy of the Dynamic Deconstructive Psychotherapy to improve the symptoms in patients diagnosed with the borderline personality disorder by remediation of neuro-affective defects. This study was designed as a randomized controlled trial

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... the pre-test, post-test and a control group. Thirty patients who were diagnosed with borderline personality disorder meeting the inclusion criteria, randomly divided into two groups. Both groups evaluated using both Borderline Evaluation of Severity over Time (BEST) and Patient Health Questionnaire Mood Scale (PHQ-9) questionnaires at the baseline and the over course of the treatment. Data analysis using repeated measures ANOVA indicated that the effect of measuring time (p=0.001) and time/group (p=0.010) on linear combination of the severity of borderline disorder and depression were significant. This result supports the efficacy of Dynamic Deconstructive Psychotherapy based on the neurocognitive remediation of the emotion processing using association, attribution and alterity techniques.