Mechanisms of the beneficial effect of sevoflurane in liver ischemia/reperfusion injury

Fernanda Paula Cavalcante, Ana Maria Mendonça Coelho, Marcel Cerqueira Cesar Machado, Sandra Nassa Sampietre, Rosely Antunes Patzina, Márcio Augusto Diniz, Eleazar Chaib, Luiz Augusto Carneiro D'Albuquerque
2015 Acta Cirurgica Brasileira  
PURPOSE: To evaluate the underlying mechanisms by which sevoflurane protects the liver against ischemia/reperfusion injury evaluate the mechanism by which sevoflurane exerts this protective effect. METHODS: Twenty-six rats were subjected to partial ischemia/reperfusion injury for 1h: one group received no treatment, one group received sevoflurane, and sham group of animals received laparotomy only. Four hours after reperfusion, levels of alanine and aspartate aminotransferases, tumor necrosis
more » ... s, tumor necrosis factor-α, and interleukins 6 and 10 were measured. Analyses of mitochondrial oxidation and phosphorylation, malondialdehyde content, histology, and pulmonary vascular permeability were performed. RESULTS : Serum levels of alanine and aspartate aminotransferases were significantly lower in the sevoflurane group compared to untreated controls (p<0.05). The sevoflurane group also showed preservation of liver mitochondrial function compared to untreated controls (p<0.05). Sevoflurane administration did not alter increases in serum levels of tumor necrosis factor-α, and interleukins 6 and 10. Sevoflurane treatment significantly reduced the coagulative necrosis induced by ischemia/reperfusion (p<0.05). Pulmonary vascular permeability was preserved in the sevoflurane group compared to untreated controls. CONCLUSION: Sevoflurane administration protects the liver against ischemia/reperfusion injury, via preservation of mitochondrial function, and also preserves lung vascular permeability.
doi:10.1590/s0102-865020150110000005 pmid:26647794 fatcat:lwnhs24oxrdajehd3h7mpksj74