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Distinct roles for the mammalian A-type cyclins during oogenesis
There are two A-type cyclins in higher vertebrates, cyclin A1 and A2. Targeted mutagenesis has shown that cyclin A2 is essential for early embryonic development while cyclin A1 is required only for male meiosis. The embryonic lethality of cyclin A2 knockout mice has obviated understanding its role in other aspects of mammalian development, including the germ line. We reported previously that cyclin A2 expression in the male germ line is consistent with a role in both mitotic and meiotic celldoi:10.1530/rep.1.00719 pmid:16183859 fatcat:v6koxvqnxzeynird54afo5p4dm