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Human AKTIP interacts with ESCRT proteins and functions at the midbody in cytokinesis
To complete mitosis, the intercellular bridge that links daughter cells needs to be cleaved. This abscission step is carried out by the sequential recruitment of ESCRT proteins at the midbody. We report here that a new factor, named AKTIP, works in association with ESCRTs. We find that AKTIP binds to the ESCRT I subunit VPS28, and show by high resolution microscopy that AKTIP forms a ring in the dark zone of the intercellular bridge. This ring is positioned in between the circular structuresdoi:10.1101/2020.01.19.911891 fatcat:tvz2t4lnovhpnht5mde3z7itaa