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Microscopic structural study of collagen aging in isolated fibrils using polarized second harmonic generation
2012
Journal of Biomedical Optics
Preserved Fulltext
Polarization resolved second harmonic generation (PSHG) is developed to study, at the microscopic scale, the impact of aging on the structure of type I collagen fibrils in two-dimensional coatings. A ribose-glycated collagen is also used to mimic tissue glycation usually described as an indicator of aging. PSHG images are analyzed using a generic approach of the molecular disorder information in collagen fibrils, revealing significant changes upon aging, with a direct correlation between
doi:10.1117/1.jbo.17.8.080506
pmid:23224157
fatcat:2rsscvcpgzg5bgsncyqew6shsm