A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit <a rel="external noopener" href="http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4004703&blobtype=pdf">the original URL</a>. The file type is <code>application/pdf</code>.
DREADDs: novel tools for drug discovery and development
<span title="">2014</span>
<i title="Elsevier BV">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/q2rzh4rosrd2rhrlmpfocas4qa" style="color: black;">Drug Discovery Today</a>
</i>
Preserved Fulltext
Since the invention of the first designer receptors exclusively activated by designer drugs (DREADDs), these engineered G protein-coupled receptors (GPCRs) have been widely applied in investigations of biological processes and behaviors. DREADD technology has emerged as a powerful tool with great potential for drug discovery and development. DREADDs can facilitate the identification of druggable targets and enable researchers to explore the activities of novel drugs against both known and
<span class="external-identifiers">
<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.drudis.2013.10.018">doi:10.1016/j.drudis.2013.10.018</a>
<a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24184433">pmid:24184433</a>
<a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4004703/">pmcid:PMC4004703</a>
<a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jsofekpezbdhtctkb3savhdome">fatcat:jsofekpezbdhtctkb3savhdome</a>
</span>
more »
... GPCRs. Here, we discuss how DREADDs can be used as novel tools for drug discovery and development.
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200211015604/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4004703&blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext">
<button class="ui simple right pointing dropdown compact black labeled icon button serp-button">
<i class="icon ia-icon"></i>
Web Archive
[PDF]
<div class="menu fulltext-thumbnail">
<img src="https://blobs.fatcat.wiki/thumbnail/pdf/56/18/5618bd18610e9373f6ae0a87eca7eeb215608e1c.180px.jpg" alt="fulltext thumbnail" loading="lazy">
</div>
</button>
</a>
<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.drudis.2013.10.018">
<button class="ui left aligned compact blue labeled icon button serp-button">
<i class="external alternate icon"></i>
elsevier.com
</button>
</a>
<a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004703" title="pubmed link">
<button class="ui compact blue labeled icon button serp-button">
<i class="file alternate outline icon"></i>
pubmed.gov
</button>
</a>