Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum

Qian-Nan Xu, Dan Zhu, Guang-Hui Wang, Ting Lin, Cui-Ling Sun, Rong Ding, Wen-Jing Tian, Hai-Feng Chen
2020 Figshare  
Descaudatine A (1), an undescribed phenolic glycoside, along with a known analogue (2) and ten flavonoids (3-12), were isolated from the whole plant of Desmodium caudatum. Compounds 1 and 4 exhibited potent antioxidant activities with the IC50 of 58.59 μM and 31.31 μM, respectively, which were approached to that of the positive control Vitamin C (IC50 = 46.32 μM). Meanwhile, 12 showed moderate antioxidant activity with the IC50 of 173.9 μM. Besides, compounds 3 and 6 inhibited the proliferation
more » ... d the proliferation of HeLa cells with IC50 values of 56.14 μM and 69.04 μM, respectively. Further studies indicated that 3 and 6 could dose-dependently induce PARP cleavage and might trigger caspase-3, 8, 9 activation to induce apoptosis. RXRα is an ideal anticancer target of nuclear receptor. The reporter gene assay of RXRα indicated that 3 and 6 could inhibited the 9-cis-RA induced RXRα transcription in a concentration-dependent manner.
doi:10.6084/m9.figshare.11973606.v1 fatcat:dmsvpj3t4bdwlczbcgxga2lw2e