Protective role of the calcium channel blocker amlodipine against mitochondrial injury in ischemia and reperfusion injury of rat liver

Chattopadhyay Pronobesh, Aher Dagagi, Chaudhury Pallab, Wahi Kumar
2008 Acta Pharmaceutica  
Mitochondria are the principal targets in the development of ischemia-reperfusion (I/R) induced hepatic injury (1, 2). Increased production of superoxide radicals at the level of the mitochondrial respiratory chain is allegedly a major participant in I/R injury (2). Oxidant stress induced cell killing involves oxidation of pyridine nucleotides, accu-421 Acta Pharm. 58 (2008) [421][422][423][424][425][426][427][428] Original research paper
doi:10.2478/v10007-008-0022-3 pmid:19103576 fatcat:dctb5prgcbhh5cgxnebly7s64m