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Impact of Biocompatible Poly(ethylene glycol)-block-Poly(ε-caprolactone) Nano-Micelles on the Antifungal Efficacy of Voriconazole
Biointerface Research in Applied Chemistry
This study aimed to encapsulate voriconazole into nano-micelles of poly(ethylene glycol)-block-poly(ε-caprolactone) to enhance its antifungal activity and reduce the required doses. The nano-micelles were prepared at various drug/polymer ratios, and their various physicochemical properties were studied. The nano-micelles had a small particle size in the range of ~50-60 nm and homogenous size distribution. The nano-micelles had high encapsulation efficiency and loading capacity in the range ofdoi:10.33263/briac131.062 fatcat:pdwpbjdop5hyhhoogewloeqjlm